Chlorosuccinimide → 1-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone

HRID 2276315Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2276315
[Cl:1]N1C(=O)CCC1=O.[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]>CN(C=O)C>[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([Cl:1])[C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]

Komponenten

4

Edukt 2

HCID 31398ChlorosuccinimideHCID 594970761-butyl-4-hydroxy-1H-pyridine-2-one

Produkt 1

HCID 594970741-butyl-3-chloro-4-hydroxy-2(1H)-PyridinoneAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

N-Chlorosuccinimide (1.6 g, 11.96 mmol) was added to a solution of intermediate D5 (2.0 g, 11.96 mmol) in DMF (30 ml). The reaction was stirred at room temperature overnight and then it was concentrated in vacuo. The crude product was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent) to yield intermediate D8 (2.0 g, 83%).

Aufarbeitung

  1. concentrationit was concentrated in vacuo
  2. customThe crude product was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent)

Quellen und Nachweise

ORD-Eintrag
ord-35745f7d93154ed8bc95101e812b8531
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09132122B2

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