Sodium Hydroxide → 3-(3-Fluorophenyl)-5-methylisoxazole-4-carboxylic acid
Reaktionsgleichung
C[O:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=[O:4].[OH-].[Na+]>CO>[F:17][C:13]1[CH:12]=[C:11]([C:6]2[C:5]([C:3]([OH:4])=[O:2])=[C:9]([CH3:10])[O:8][N:7]=2)[CH:16]=[CH:15][CH:14]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In a similar manner as described in Preparation Example 25, by using methanol (60 mL), methyl-3-(3-fluorophenyl)-5-methylisoxazol-4-carboxylate (6.0 g, 25.51 mmol) and 3% sodium hydroxide aqueous solution (60 mL), a white solid required compound (5.51 g, 24.92 mmol, 98%) was obtained.
Aufarbeitung
- customIn a similar manner as described in Preparation Example 25
Quellen und Nachweise
- ORD-Eintrag
- ord-d09ca920cff74cb98e6432eec3254b25
- Quelldatensatz
- uspto-grants-2015_09
- Patentnummer
- US09132126B2
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