Trifluoroacetic acid → HCID 86719965, Verbindung

To a clear solution of trans-3-{N′-(6-carboxymethoxy-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carbonyl)-hydrazinocarbonyl}-(R)-piperidin-1-carboxylic acid tert-butyl ester (150 mg, 0.32 mmol) in dichloromethane (2 ml) was added trifluoroacetic acid under stirring at −10° C. The reaction mixture was stirred for about 1 hour at −10° C. and the solvents were evaporated under vacuum to provide a residue. The residue was triturated successively with diethyl ether (25 ml) and acetonitrile (25 ml) and solvents were decanted to provide solid that was dried under vacuum to provide 59 mg of titled compound in 50% yield.

1. stirringThe reaction mixture was stirred for about 1 hour at −10° C.
2. customthe solvents were evaporated under vacuum
3. customto provide a residue
4. customThe residue was triturated successively with diethyl ether (25 ml) and acetonitrile (25 ml) and solvents
5. customwere decanted
6. customto provide solid
7. customthat was dried under vacuum

ORD-Eintrag

ord-dcf7c3c6fc7a4fcdb40290c872dcf7e6

Quelldatensatz

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09132133B2