Methanol → HCID 67453617, Verbindung

HRID 2276743Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2276743
[Na].F[C:3]1[N:8]=[C:7]([C:9]2([C:13]#[N:14])[CH2:12][CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=1.[CH3:15][OH:16]>>[CH3:15][O:16][C:3]1[N:8]=[C:7]([C:9]2([C:13]#[N:14])[CH2:12][CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 5360545SodiumHCID 67452252HCID 67452252, Verbindung

Produkt 1

HCID 67453617HCID 67453617, VerbindungAusbeute 97 %

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

To stirred 6.0 mL of anhydrous methanol at 0° C. under nitrogen was added sodium metal (˜1 g) and the mixture stirred for 30 minutes. To this was added 1-(6-fluoropyridin-2-yl)cyclobutanecarbonitrile (1.6 g, 9.1 mmol, 1.0 equiv) and the resulting mixture heated to 75° C. for 45 minutes. The solution was cooled to room temperature and partitioned between water and EtOAc. The layers were separated, the aqueous phase was extracted with EtOAc, and the combined organic phases were washed with saturated NaCl, dried over Na2SO4 and concentrated in vacuo to give the desired product (1.7 g, 97%) as a colorless oil.

Aufarbeitung

  1. temperatureThe solution was cooled to room temperature
  2. custompartitioned between water and EtOAc
  3. customThe layers were separated
  4. extractionthe aqueous phase was extracted with EtOAc
  5. washthe combined organic phases were washed with saturated NaCl
  6. dry with materialdried over Na2SO4
  7. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7d2b9917e7c04abab511d9037fd72260
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09133123B2

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