HCID 57517503, Verbindung → 4-(Cyclopropylmethoxy)-3-fluorobenzenamine

HRID 2277153Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2277153
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][C:7]=2[F:15])[CH2:3][CH2:2]1>[C].[Pd].C1COCC1>[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][C:7]=2[F:15])[CH2:2][CH2:3]1

Komponenten

4

Edukt 1

HCID 57517503HCID 57517503, Verbindung

Produkt 1

HCID 196272444-(Cyclopropylmethoxy)-3-fluorobenzenamineAusbeute 99,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 1-(cyclopropylmethoxy)-2-fluoro-4-nitrobenzene (3.00 g), 10% palladium-carbon (containing water (50%), 3.00 g) and THF (30 mL) was stirred at room temperature for 1 hr under a hydrogen atmosphere. The catalyst was removed by filtration, and the obtained filtrate was concentrated under reduced pressure to give the title compound (2.57 g).

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-83e46c465d924d5cb0690b86679b2380
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09133129B2

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