Ethyl Acetate → 4-(cyclopropylmethoxy)-N-(4,6-dichloropyridin-3-yl)benzamide

HRID 2277178Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2277178
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][C:3]=1[NH2:9].[CH:10]1([CH2:13][O:14][C:15]2[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=2)[CH2:12][CH2:11]1.C(OCC)(=O)C>N1C=CC=CC=1.C1COCC1>[CH:10]1([CH2:13][O:14][C:15]2[CH:16]=[CH:17][C:18]([C:19]([NH:9][C:3]3[CH:4]=[N:5][C:6]([Cl:8])=[CH:7][C:2]=3[Cl:1])=[O:20])=[CH:22][CH:23]=2)[CH2:12][CH2:11]1

Komponenten

6

Edukt 3

HCID 8857Ethyl AcetateHCID 5957294,6-Dichloropyridin-3-amineHCID 867312344-(Cyclopropylmethoxy)benzoyl chloride

Produkt 1

HCID 867312334-(cyclopropylmethoxy)-N-(4,6-dichloropyridin-3-yl)benzamideAusbeute 36,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 4,6-dichloropyridin-3-amine (2.00 g) in pyridine (30 mL) was added a solution of 4-(cyclopropylmethoxy)benzoyl chloride (3.88 g) in THF (5 mL), and the mixture was stirred at room temperature for 10 min. The reaction mixture was subjected to silica gel column chromatography (NH, ethyl acetate), and the solvent was evaporated, and the obtained solid was washed with diethyl ether/hexane to give the title compound (1.50 g).

Aufarbeitung

  1. customthe solvent was evaporated
  2. washthe obtained solid was washed with diethyl ether/hexane

Quellen und Nachweise

ORD-Eintrag
ord-66fdf7dd845747758c5b14d7fc8c2717
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09133129B2

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