Reaktionsgleichung
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([O:13][CH2:14][CH:15]2[CH2:17][C:16]2([F:19])[F:18])(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]>CCCCCC.C(O)C>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([S:10]([O:13][CH2:14][C@H:15]2[CH2:17][C:16]2([F:19])[F:18])(=[O:11])=[O:12])=[CH:8][CH:9]=1)([O-:3])=[O:2]Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A racemate (48.4 g) of (2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate was resolved by HPLC (column: CHIRALPAK AD (trade name), 50 mmID×500 mL, DAICEL CHEMICAL INDUSTRIES, LTD., mobile phase:hexane/ethanol=50:50) to give the title compound having a shorter retention time (18.4 g). The steric configuration was determined by X ray structure analysis.
Quellen und Nachweise
- ORD-Eintrag
- ord-526adb8677db4def9905f42d2676670e
- Quelldatensatz
- uspto-grants-2015_09
- Patentnummer
- US09133129B2
Verknüpfte Notizen
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