2-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine → HCID 89444666, Verbindung
Reaktionsgleichung
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH3:16])[C:5]([F:17])=[CH:4][N:3]=1.[N+:18]([C:21]1[CH:22]=[C:23]([CH2:33][OH:34])[CH:24]=[C:25]([S:27]([F:32])([F:31])([F:30])([F:29])[F:28])[CH:26]=1)([O-])=O>>[F:17][C:5]1[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH3:16])=[N:7][C:2]([NH:18][C:21]2[CH:22]=[C:23]([CH2:33][OH:34])[CH:24]=[C:25]([S:27]([F:32])([F:28])([F:29])([F:30])[F:31])[CH:26]=2)=[N:3][CH:4]=1Komponenten
3
Versuchsvorschrift
Intermediate 60.4 was prepared under similar conditions as described in the preparation of Intermediate 20.1 using 2-chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine and [3-nitro-5-(pentafluoro-λ6-sulfanyl)phenyl]methanol. The batch was purified by chromatography (DCM/EtOH 9:1) to give the desired product.
Aufarbeitung
- customThe batch was purified by chromatography (DCM/EtOH 9:1)