Trifluoroacetic acid → HCID 89676991, Verbindung

HRID 2278254Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2278254
[CH3:1][C:2]1[C:7]([CH2:8][N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[CH:6][CH:5]=[C:4]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH3:28])[N:3]=1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][C:2]1[C:7]([CH2:8][N:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)=[CH:6][CH:5]=[C:4]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH3:28])[N:3]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 89677097HCID 89677097, Verbindung

Produkt 1

HCID 89676991HCID 89676991, VerbindungAusbeute 87,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A 100 mL round-bottom flask was charged with tert-butyl 4-[[2-methyl-6-(2-methylphenyl)pyridin-3-yl]methyl]piperazine-1-carboxylate (800 mg, 2.40 mmol, 1.00 equiv), dichloromethane (20 mL), trifluoroacetic acid (4 mL) was added dropwise. The resulting solution was stirred overnight at room temperature. The resulting mixture was concentrated under reduced pressure to provide 590 mg (crude) of 1-[[2-methyl-6-(2-methylphenyl)pyridin-3-yl]methyl]piperazine as yellow oil. LCMS (ESI, m/z): 282 [M+H]+.

Aufarbeitung

  1. additionwas added dropwise
  2. concentrationThe resulting mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3621a89bc93841eab2084f5dcb3a0e4e
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09133148B2

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