Trifluoroacetic acid → Piperazine, 1-[[5-(3-fluorophenyl)-2-pyridinyl]methyl]-

HRID 2278271Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2278271
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][N:15]3[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 89677105HCID 89677105, Verbindung

Produkt 1

HCID 89676965Piperazine, 1-[[5-(3-fluorophenyl)-2-pyridinyl]methyl]-Ausbeute 72 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A 100 mL round-bottom flask, was charged with tert-butyl 4-[[5-(3-fluorophenyl)pyridin-2-yl]methyl]piperazine-1-carboxylate (950 mg, 2.56 mmol, 1.00 equiv), dichloromethane (15 mL), trifluoroacetic acid (2 mL). The resulting solution was stirred for overnight at room temperature. The resulting mixture was concentrated under reduced pressure to provide 500 mg (crude) of 1-[[5-(3-fluorophenyl)pyridin-2-yl]methyl]piperazine as yellow oil. LCMS (ESI, m/z): 272 [M+H]+.

Aufarbeitung

  1. concentrationThe resulting mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1d95816ae3ec4a22abb7fdca3ecbfdbe
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09133148B2

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