Ambroxol → (1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetic acid--4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexan-1-ol (1/1)

HRID 2278836

Reaktionsgleichung

Reaktionsgleichung von HRID 2278836
[CH2:1]1[CH:6]([NH:7][CH2:8][C:9]2[C:14]([NH2:15])=[C:13]([Br:16])[CH:12]=[C:11]([Br:17])[CH:10]=2)[CH2:5][CH2:4][CH:3]([OH:18])[CH2:2]1.[N:19]1([C:30](=[O:31])[C:29]2[N:28]([CH2:32][C:33]([OH:35])=[O:34])[CH:27]=[N:26][C:25]=2[N:23]([CH3:24])[C:21]1=[O:22])[CH3:20]>C(Cl)(Cl)Cl>[CH3:24][N:23]1[C:21](=[O:22])[N:19]([CH3:20])[C:30](=[O:31])[C:29]2[N:28]([CH2:32][C:33]([OH:35])=[O:34])[CH:27]=[N:26][C:25]1=2.[CH2:5]1[CH:6]([NH:7][CH2:8][C:9]2[C:14]([NH2:15])=[C:13]([Br:16])[CH:12]=[C:11]([Br:17])[CH:10]=2)[CH2:1][CH2:2][CH:3]([OH:18])[CH2:4]1

Komponenten

4

Edukt 2

HCID 2132Ambroxol2×HCID 69550Acefylline

Produkt 1

HCID 176595(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetic acid--4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexan-1-ol (1/1)

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel3×

Reaktionsbedingungen

Temperatur
62.5 °C

Versuchsvorschrift

Ambroxol base (20.0 g, 0.052 moles) was dissolved in chloroform (100 ml) at room temperature. Chloroform (100 ml) and theophylline-7-acetic acid (12.6 g, 0.052 moles) were charged in a round bottom flask and heated at 60 to 65° C. To this flask, the prepared solution of ambroxol base in chloroform was added under stirring while maintaining the temperature between 60-65° C. during 2-3 minutes. The resulting reaction mixture was stirred at 60-65° C. for 25-30 minutes. The reaction mixture was allowed to cool to room temperature. The separated solid product was filtered and washed with chloroform and dried. The yield of Acebrophylline obtained was 97.8%.

Aufarbeitung

  1. temperaturewhile maintaining the temperature between 60-65° C. during 2-3 minutes
  2. customThe resulting reaction mixture
  3. stirringwas stirred at 60-65° C. for 25-30 minutes
  4. temperatureto cool to room temperature
  5. filtrationThe separated solid product was filtered
  6. washwashed with chloroform
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-de2d709f7c914403ac17e3f500fa2ebb
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09133196B2

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