Ethanol → HCID 178440334, Verbindung

HRID 2278860Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2278860
O=[C:2]([CH2:7][CH2:8][CH3:9])[C:3]([O:5]C)=O.[F:10][C:11]1[CH:30]=[CH:29][CH:28]=[CH:27][C:12]=1[CH2:13][N:14]1[C:18]2=[N:19][CH:20]=N[CH:22]=[C:17]2[C:16]([C:23](=[NH:26])[NH:24][NH2:25])=[N:15]1.[CH2:31](O)C>>[F:10][C:11]1[CH:30]=[CH:29][CH:28]=[CH:27][C:12]=1[CH2:13][N:14]1[C:18]2=[N:19][CH:20]=[CH:31][CH:22]=[C:17]2[C:16]([C:23]2[N:24]=[N:25][C:2]([CH2:7][CH2:8][CH3:9])=[C:3]([OH:5])[N:26]=2)=[N:15]1

Komponenten

4

Edukt 3

HCID 702Ethanol2×HCID 642256Methyl 2-OxovalerateHCID 178512736HCID 178512736, Verbindung

Produkt 1

HCID 178440334HCID 178440334, Verbindung

Versuchsvorschrift

0.916 g (7.035 mmol) of methyl 2-oxopentanoate in 15 ml of ethanol were initially introduced and heated to reflux. Then, 2.000 g (7.035 mmol) of 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidohydrazide suspended in 20 ml of ethanol were added and the mixture was heated under reflux overnight. After cooling, the mixture was filtered off with suction, and the filtercake was washed with a little ethanol and dried under high vacuum. This gave 1.75 g of the target compound (purity 92%; 63% of theory).

Aufarbeitung

  1. temperatureheated to reflux
  2. additionwere added
  3. temperaturethe mixture was heated
  4. temperatureunder reflux overnight
  5. temperatureAfter cooling
  6. filtrationthe mixture was filtered off with suction
  7. washthe filtercake was washed with a little ethanol
  8. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-00eec5bf659c4cf48ab0c61a2325d3a0
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09133191B2

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