Ethanol → Ethyl 5-ethoxy-1H-pyrazole-3-carboxylate
Reaktionsgleichung
[CH2:1]([O:3][C:4](=[O:12])[CH2:5][C:6](=O)[C:7](Cl)(Cl)Cl)[CH3:2].[NH2:13][NH2:14].Cl.[CH3:16][CH2:17][OH:18]>>[CH2:1]([O:3][C:4]([C:5]1[NH:13][N:14]=[C:7]([O:18][CH2:17][CH3:16])[CH:6]=1)=[O:12])[CH3:2]Komponenten
4
Versuchsvorschrift
4,4,4-Trichloro-3-oxo-butyric acid ethyl ester (Int 8, 1 eq) and H2NNH2.HCl (1.1 eq) are mixed in EtOH. The resulting mixture is refluxed overnight. The mixture is then evaporated and the obtained crude is purified by chromatography to give Int 9 and 5-ethoxy-2H-pyrazole-3-carboxylic acid ethyl ester (Int 10).
Aufarbeitung
- temperatureThe resulting mixture is refluxed overnight
- customThe mixture is then evaporated
- customthe obtained crude
- customis purified by chromatography
Quellen und Nachweise
- ORD-Eintrag
- ord-31cc93264c994d118e695060f06583d0
- Quelldatensatz
- uspto-grants-2015_09
- Patentnummer
- US09133210B2
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