3-Hydroxybutyric Acid → (-)-3-t-Butyldimethylsilyloxybutyric acid

HRID 2279205Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2279205
[OH:1][CH:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5].[CH3:8][C:9]([Si:12](Cl)([CH3:14])[CH3:13])([CH3:11])[CH3:10]>C(Cl)Cl>[C:9]([Si:12]([CH3:14])([CH3:13])[O:1][CH:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5])([CH3:11])([CH3:10])[CH3:8]

Komponenten

4

Edukt 2

HCID 4413-Hydroxybutyric AcidHCID 28928tert-Butyldimethylsilyl chloride

Produkt 1

HCID 13712781(-)-3-t-Butyldimethylsilyloxybutyric acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3-Hydroxy-butyric acid (500 mg, 4.8 mmol) is dissolved in a mixture of TBSCl (1.5 g, 10.1 mmol) in dry DCM (48 mL). The resulting mixture is stirred overnight at room temperature. The resulting suspension is then filtered and the obtained residues are washed with DCM, then stirred in Et2O and filtered. The obtained filtrate is evaporated to give the desired product that is used as such.

Aufarbeitung

  1. filtrationThe resulting suspension is then filtered
  2. washthe obtained residues are washed with DCM
  3. stirringstirred in Et2O
  4. filtrationfiltered
  5. customThe obtained filtrate is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-d48cd4783ab941b89a970aa392636394
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09133210B2

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