Pyrrolidine → (2S)-2-hydroxy-1-(1-pyrrolidinyl)-1-propanone

HRID 2279466Notizen

Reaktionsgleichung

[OH:1][C@@H:2]([CH3:7])[C:3](OC)=[O:4].[NH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1>>[OH:1][C@@H:2]([CH3:7])[C:3]([N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:4]

Komponenten

Edukt 2

HCID 31268Pyrrolidine

HCID 94386methyl (S)-lactate

Produkt 1

HCID 11051776(2S)-2-hydroxy-1-(1-pyrrolidinyl)-1-propanoneAusbeute 99,7 %

Versuchsvorschrift

(S)-Methyl 2-hydroxypropanoate (30.0 g, 288 mmol) and pyrrolidine (22.5 g, 317 mmol) were stirred at RT for 3 d. The crude product was purified by passing through a SiO2 plug eluting with 80% EtOAc/hexane to afford 41.1 g (99.6%) (S)-2-hydroxy-1-(pyrrolidin-1-yl)propan-1-one (108).

Aufarbeitung

customThe crude product was purified
washeluting with 80% EtOAc/hexane

Quellen und Nachweise

ORD-Eintrag: ord-fe1ba449fc2b4abe88e5ee84c5516a65
Quelldatensatz: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09133187B2

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