Hydrochloric Acid → HCID 86705500, Verbindung
Reaktionsgleichung
[F:1][C:2]1([F:26])[C:11]2[CH:10]=[N:9][C:8]([NH:12][CH:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[N:7][C:6]=2[CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[ClH:27].CC(O)C>C(Cl)Cl>[ClH:27].[F:26][C:2]1([F:1])[C:11]2[CH:10]=[N:9][C:8]([NH:12][CH:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)=[N:7][C:6]=2[CH2:5][NH:4][CH2:3]1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a stirred solution of 206 (215 mg, 0.5805 mmol) in DCM (4 mL) at RT under nitrogen was added 5M HCl in IPA (1.161 mL, 5.805 mmol) by pipet. After stirring overnight, the reaction was concentrated to dryness by rotovap and high vacuum to afford 106 mg (100%) of 5,5-difluoro-N-(tetrahydro-2H-pyran-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-amine hydrochloride (208) which was used without additional purification.