Sodium Hydroxide → 5-Benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid

HRID 2279642Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2279642
[OH-].[Na+].C[O:4][C:5]([C:7]1[C:8]([CH3:20])=[N:9][N:10]([CH3:19])[C:11]=1[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:6]>CO>[CH2:12]([C:11]1[N:10]([CH3:19])[N:9]=[C:8]([CH3:20])[C:7]=1[C:5]([OH:6])=[O:4])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 154462275-benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid methyl ester

Produkt 1

HCID 595799845-Benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

NaOH (10 N, 7 mL) is added to a solution of 5-benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid methyl ester (680 mg, 2.78 mmol) in MeOH (10 mL) at RT. The mixture is heated to 50° C. for 4 h. The solvent is removed to dryness. H2O is added and pH is adjusted to 5 using aq. HCl. The solid is filtered and dried to give the title compound.

Aufarbeitung

  1. customThe solvent is removed to dryness
  2. additionH2O is added
  3. filtrationThe solid is filtered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-addbbf4343454f61b3a7044fb462cd9f
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09133204B2

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