Sodium Hydroxide → (Pyrimidin-4-yl)acetic acid

HRID 2280166Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2280166
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([O:10]CC)=[O:9])=[N:3][CH:2]=1.[OH-].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([OH:10])=[O:9])=[N:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 20295406Ethyl 2-(pyrimidin-4-yl)acetate

Produkt 1

HCID 21486925(Pyrimidin-4-yl)acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of ethyl 2-(pyrimidin-4-yl)acetate (Example 33b, 450 mg. 2.71 mmol) in ethanol (5 mL) was added 2N NaOH (2 mL) at room temperature under nitrogen. The reaction mixture was stirred at room temperature under nitrogen for 24 hours, concentrated under reduced pressure and suspended in ethanol. The solid was removed by vacuum filtration, and the filtrate was concentrated under reduced pressure, triturated with ethanol, concentrated again and carried onto the next step without further purification. MS139 (MH+).

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. customThe solid was removed by vacuum filtration
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customtriturated with ethanol
  5. concentrationconcentrated again
  6. customcarried onto the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-07c2ef4d898640b8b055a75f93049263
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09138013B2

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