HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,3,4-Thiadiazole, 2-amino-5-methyl- → HCID 57756824, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,3,4-Thiadiazole, 2-amino-5-methyl- | HCID 66949 | — |
| Edukt | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| Produkt | HCID 57756824 | HCID 57756824 | 62,1% |
Reaktionsschritte
In a similar manner to Example 87, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 2-amino-5-methyl-1,3,4-thiadiazole (39.2 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-[N-(5-methyl-1,3,4-thiadiazol-2-yl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (40.4 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07560569B2 |
| Quelldatensatz | uspto-grants-2009_07 |
| ORD ID | ord-49fde23645074c4286724e028fee7baf |
| Quellennotiz | uspto-grants-2009_07 |