HOAt → n-{(1r)-1-[(4-Chlorophenyl)methyl]-2-oxo-2-[4-(2-pyridylmethyl)piperazinyl]ethyl}(tert-butoxy) carboxamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	HOAt	HCID 181649	—
Edukt	1-[(Pyridin-2-yl)methyl]piperazine	HCID 808714	—
Edukt	N-Boc-4-chloro-D-phenylalanine	HCID 7018791	—
Edukt	N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide methyliodide	HCID 10236463	—
Lösungsmittel	Dimethylformamide	HCID 6228	—
Produkt	n-{(1r)-1-[(4-Chlorophenyl)methyl]-2-oxo-2-[4-(2-pyridylmethyl)piperazinyl]ethyl}(tert-butoxy) carboxamide	HCID 69073501	—

Reaktionsschritte

N-{(1R)-1-[(4-Chlorophenyl)methyl]-2-oxo-2-[4-(2-pyridylmethyl)piperazinyl]ethyl}(tert-butoxy)carboxamide was prepared according to the procedure for Preparation XIX using (2-pyridylmethyl)piperazine (650 mg. 3.7 mmol) (Array), Boc-p-Cl-D-Phe-OH (1.1 g, 3.7 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide methiodide (2.2 g, 7.2 mmol), HOAT (560 mg, 4.10 mmol) and DMF (15 mL) (730 mg). MS (ESI, pos. ion) m/z: 459 (M+H), (ESI, neg. ion) m/z: 457 (M−H). Calc'd for C24H31ClN4O3: 458.98.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07560460B2
Quelldatensatz	uspto-grants-2009_07
ORD ID	ord-40b14d33b26f4cce8279dc28406e7bd2
Quellennotiz	uspto-grants-2009_07