2-Aminobenzenesulfonamide → HCID 42643896, Verbindung

HRID 2283280Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2283280
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][S:21](Cl)(=[O:23])=[O:22])=[CH:15][CH:14]=1>N1C=CC=CC=1>[Cl:12][C:13]1[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][S:21]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[S:8]([NH2:11])(=[O:9])=[O:10])(=[O:23])=[O:22])=[CH:17][CH:18]=1

Komponenten

4

Edukt 2

HCID 728942-AminobenzenesulfonamideHCID 27577802-(4-Chlorophenyl)ethane-1-sulfonyl chloride

Produkt 1

HCID 42643896HCID 42643896, VerbindungAusbeute 8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

2-Aminobenzenesulfonamide (0.52 g, 3 mmol) was dissolved in pyridine (20 mL) followed by addition of 2-(4-chlorophenyl)ethanesulfonyl chloride (0.80 g, 3.3 mmol) and the reaction was stirred at RT overnight. The solvent was then removed under reduced pressure and the crude material was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer) to give the title compound (87 mg, 8%) as a white solid.

Aufarbeitung

  1. customThe solvent was then removed under reduced pressure
  2. customthe crude material was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer)

Quellen und Nachweise

ORD-Eintrag
ord-7eaf9a4caf1943668d561655c9d0b9e6
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09145380B2

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