2-Aminobenzenesulfonamide → HCID 57750902, Verbindung

HRID 2283292Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2283292
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[F:12][C:13]1[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:14]=1[S:20](Cl)(=[O:22])=[O:21]>N1C=CC=CC=1>[F:12][C:13]1[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:14]=1[S:20]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](=[O:9])(=[O:10])[NH2:11])(=[O:22])=[O:21]

Komponenten

4

Edukt 2

HCID 728942-AminobenzenesulfonamideHCID 218690652,3-Difluorobenzene-1-sulfonyl chloride

Produkt 1

HCID 57750902HCID 57750902, VerbindungAusbeute 58 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

2-Aminobenzenesulfonamide (26 mg, 0.15 mmol) was dissolved in pyridine (1 ml) and 2,3-difluorophenylsulfonyl chloride (19 μl, 0.15 mmol) was added and the reaction stirred overnight. The solvent was removed in vacuo and the residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer) to give the title compound (30 mg, 58%).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer)

Quellen und Nachweise

ORD-Eintrag
ord-9548669f86c64afbbc317c705e043bf3
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09145380B2

Notizen zur Reaktion

Wird geladen…