2,3-Difluorobenzene-1-sulfonyl chloride → HCID 57751038, Verbindung

HRID 2283293Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2283293
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].[F:13][C:14]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=1[S:21](Cl)(=[O:23])=[O:22]>N1C=CC=CC=1>[F:13][C:14]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=1[S:21]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[S:9](=[O:11])(=[O:10])[NH2:12])(=[O:23])=[O:22]

Komponenten

4

Edukt 2

HCID 218690652,3-Difluorobenzene-1-sulfonyl chlorideHCID 224818252-Amino-5-fluorobenzenesulfonamide

Produkt 1

HCID 57751038HCID 57751038, VerbindungAusbeute 46 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

2-Amino-5-fluorobenzenesulfonamide (29 mg, 0.15 mmol) was dissolved in pyridine (1 ml) and 2,3-difluorophenylsulfonyl chloride (19 μl, 0.15 mmol) was added and the reaction stirred overnight. The solvent was removed in vacuo and the residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer) to give the title compound (25 mg, 46%).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer)

Quellen und Nachweise

ORD-Eintrag
ord-90068a253ac7493f8ac7190cdebc4c47
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09145380B2

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