2-Amino-5-chlorobenzenesulphonamide → (E)-5-chloro-2-(2-(4-chloro-2-methoxyphenyl)vinylsulfonamido)benzenesulfonamide

HRID 2283335Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2283335
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].[Cl:13][C:14]1[CH:19]=[CH:18][C:17](/[CH:20]=[CH:21]/[S:22](Cl)(=[O:24])=[O:23])=[C:16]([O:26][CH3:27])[CH:15]=1>N1C=CC=CC=1>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][S:22](/[CH:21]=[CH:20]/[C:17]2[CH:18]=[CH:19][C:14]([Cl:13])=[CH:15][C:16]=2[O:26][CH3:27])(=[O:23])=[O:24])=[C:3]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:4]=1

Komponenten

4

Edukt 2

HCID 122955502-Amino-5-chlorobenzenesulphonamideHCID 22711054(E)-2-(4-chloro-2-methoxyphenyl)ethenesulfonyl chloride

Produkt 1

HCID 57751036(E)-5-chloro-2-(2-(4-chloro-2-methoxyphenyl)vinylsulfonamido)benzenesulfonamideAusbeute 99,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A solution of 2-amino-5-chlorobenzenesulfonamide (0.041 g, 0.20 mmol) and (E)-2-(4-chloro-2-methoxyphenyl)ethenesulfonyl chloride (0.053 g, 0.20 mmol) in pyridine (2 mL) was stirred at room temperature over night. The reaction mixture was concentrated, 1 M hydrochloric acid was added and the mixture was extracted with dichloromethane. The organic phase was dried over magnesium sulfate and the solvent was evaporated to give 0.087 g (99% yield) of the title compound.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. addition1 M hydrochloric acid was added
  3. extractionthe mixture was extracted with dichloromethane
  4. dry with materialThe organic phase was dried over magnesium sulfate
  5. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-da650443174d438fba1de736f5cb837b
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09145380B2

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