2,3-Dichlorobenzene-1-sulfonyl chloride → 2,3-Dichloro-N-(3,5-difluoro-2-sulfamoylphenyl)benzenesulfonamide
Reaktionsgleichung
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].[Cl:14][C:15]1[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=1[S:22](Cl)(=[O:24])=[O:23]>>[Cl:14][C:15]1[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=1[S:22]([NH:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[S:10](=[O:12])(=[O:11])[NH2:13])(=[O:24])=[O:23]Komponenten
3
Versuchsvorschrift
The title compound was synthesized as described for Example 194 a) in 7% yield, starting from 2-amino-4,6-difluorobenzenesulfonamide and 2,3-dichlorobenzene-1-sulfonyl chloride (1.5 equiv.). Purification by preparative HPLC.
Aufarbeitung
- customPurification by preparative HPLC