1,5-Dimethyl-1H-pyrazole-3-carboxamide → 1,5-dimethyl-1H-pyrazole-3-carbonitrile
Reaktionsgleichung
[CH3:1][N:2]1[C:6]([CH3:7])=[CH:5][C:4]([C:8]([NH2:10])=O)=[N:3]1>P(Cl)(Cl)(Cl)=O>[CH3:1][N:2]1[C:6]([CH3:7])=[CH:5][C:4]([C:8]#[N:10])=[N:3]1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The method described in Part E of Examples 1 through 4 was used to treat 1,5-dimethyl-1H-pyrazole-3-carboxamide (5.0 g, 36 mmol) with phosphorous oxychloride (20 mL) to afford 3.9 g of 1,5-dimethyl-1H-pyrazole-3-carbonitrile. A small portion was recrystallized from hexane to provide the following data.
Quellen und Nachweise
- ORD-Eintrag
- ord-a9fda43569674c1181ce8d2b201891d3
- Quelldatensatz
- uspto-grants-2015_09
- Patentnummer
- US09145410B2
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