Sodium Hydroxide → 1,2-dimethyl-6,7,8,9-tetrahydro-2H-pyrazolo[3,4-c]quinolin-4-amine

HRID 2283748

Reaktionsgleichung

Reaktionsgleichung von HRID 2283748
[CH3:1][C:2]1[N:3]([CH3:16])[N:4]=[C:5]2[C:14]=1[C:13]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N:7]=[C:6]2[NH2:15].[OH-].[Na+]>Cl>[CH3:1][C:2]1[N:3]([CH3:16])[N:4]=[C:5]2[C:14]=1[C:13]1[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=1[N:7]=[C:6]2[NH2:15]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 577175181,2-dimethyl-2H-pyrazolo[3,4-c]quinolin-4-amine

Produkt 1

HCID 577175501,2-dimethyl-6,7,8,9-tetrahydro-2H-pyrazolo[3,4-c]quinolin-4-amineAusbeute 72,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A modification of the method described in Example 13 was used to reduce 1,2-dimethyl-2H-pyrazolo[3,4-c]quinolin-4-amine (1.0 g, 4.7 mmol), prepared as described in Example 5. During the work-up procedure, the residue from the filtrate was suspended in 6 M hydrochloric acid and stirred for 30 minutes. The suspension was adjusted to pH 13 with the addition of 50% sodium hydroxide. The resulting solid was isolated by filtration, washed with water, air-dried, and recrystallized from acetonitrile to provide 0.74 g of 1,2-dimethyl-6,7,8,9-tetrahydro-2H-pyrazolo[3,4-c]quinolin-4-amine as an off-white solid, mp 258-259° C.

Aufarbeitung

  1. customprepared
  2. customThe resulting solid was isolated by filtration
  3. washwashed with water
  4. customair-dried
  5. customrecrystallized from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-d6c3af222cc14aca85e24f6ccf720c95
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09145410B2

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