Einecs 211-027-4 → HCID 66958727, Verbindung

HRID 2283835Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2283835
[CH2:1]([N:3]1[C:15]([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:14]2[C:5]([C:6]([NH2:26])=[N:7][C:8]3[CH:9]=[C:10]([O:24]C)[CH:11]=[CH:12][C:13]=32)=[N:4]1)[CH3:2].[Cl-:27].[NH+]1C=CC=CC=1>>[ClH:27].[NH2:26][C:6]1[C:5]2=[N:4][N:3]([CH2:1][CH3:2])[C:15]([CH2:16][CH2:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)=[C:14]2[C:13]2[CH:12]=[CH:11][C:10]([OH:24])=[CH:9][C:8]=2[N:7]=1

Komponenten

3

Edukt 2

HCID 69401Einecs 211-027-4HCID 57717501HCID 57717501, Verbindung

Produkt 1

HCID 66958727HCID 66958727, VerbindungAusbeute 96,3 %

Versuchsvorschrift

2-Ethyl-7-methoxy-1-(2-phenylethyl)-2H-pyrazolo[3,4-c]quinolin-4-amine (0.37 g, 1.07 mmol) was added in one portion to boiling pyridinium chloride (3.70 g, 32.0 mmol). The mixture was heated at reflux for 4 hours, and then was allowed to cool to room temperature. The mixture was triturated with ice water and the precipitate was isolated by filtration, washed with water, and dried to yield 0.38 g of 4-amino-2-ethyl-1-(2-phenylethyl)-2H-pyrazolo[3,4-c]quinolin-7-ol hydrochloride as a light grey solid, mp>300° C.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 4 hours
  3. customThe mixture was triturated with ice water
  4. customthe precipitate was isolated by filtration
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-18db397a2f9744bb86d9870fd5abc3ab
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09145410B2

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