Sulfuric Acid → 1H-Indole-2,3-dione, 6-bromo-

HRID 2284390Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2284390
S(=O)(=O)(O)[OH:2].[Br:6][C:7]1[CH:8]=[C:9]([NH:13][C:14](=[O:18])[CH:15]=NO)[CH:10]=[CH:11][CH:12]=1>>[Br:6][C:7]1[CH:8]=[C:9]2[C:10]([C:15](=[O:2])[C:14](=[O:18])[NH:13]2)=[CH:11][CH:12]=1

Komponenten

3

Edukt 2

HCID 1118Sulfuric AcidHCID 6739944Acetamide, N-(3-bromophenyl)-2-(hydroxyimino)-

Produkt 1

HCID 957161H-Indole-2,3-dione, 6-bromo-Ausbeute 98 %

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To concentrated sulfuric acid (275 mL) at 50° C. was added N-(3-bromo-phenyl)-2-hydroxyimino-acetamide (55 g, 0.2272 mol). The temperature was raised to 90° C. and maintained for 3 hours. The reaction mixture was added to ice cold water to provide a yellow precipitate. The precipitate was filtered and dried to provide the title compound as a yellow solid (50 g, 98%). This material was taken for next step without any further purification.

Aufarbeitung

  1. temperaturemaintained for 3 hours
  2. additionThe reaction mixture was added to ice cold water
  3. customto provide a yellow precipitate
  4. filtrationThe precipitate was filtered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a3a6d5efe3a14a3e8cd0dec23c0d2c65
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09145411B2

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