Tert-butyl (3-(2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)propyl)carbamate → 4-(Propylamino)pyrimidine-5-carboxamide

HRID 2284692Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2284692
C(C1C=CC(N[C:11]2[N:16]=[C:15]([NH:17][CH2:18][CH2:19][CH3:20])[C:14]([C:21]([NH:23]CCCNC(=O)OC(C)(C)C)=[O:22])=[CH:13][N:12]=2)=CC=1)(=O)N>C(Cl)(Cl)Cl.CO.FC(F)(F)C(O)=O>[CH2:18]([NH:17][C:15]1[C:14]([C:21]([NH2:23])=[O:22])=[CH:13][N:12]=[CH:11][N:16]=1)[CH2:19][CH3:20]

Komponenten

5

Edukt 1

HCID 90052173Tert-butyl (3-(2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)propyl)carbamate

Produkt 1

HCID 1317335334-(Propylamino)pyrimidine-5-carboxamideAusbeute 385,6 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 6212ChloroformLösungsmittelHCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

To a suspension of tert-butyl (3-(2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)propyl)carbamate (D2, 190 mg) in chloroform (8 mL) and methanol (2 mL), trifluoroacetic acid (1 mL) was added at room temperature, and the mixture was stirred at the same temperature for 30 minutes. The solvent was evaporated under reduced pressure to obtain N-(3-aminopropyl)-2-(4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamide (D3) trifluoroacetate (280 mg).

Aufarbeitung

  1. additionwas added at room temperature
  2. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-be3a0c69a5e844c48b450b810b856544
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09145415B2

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