Triethylamine → HCID 12928961, Verbindung

HRID 2285604Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2285604
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.C(N(CC)CC)C.[O:19]([CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][NH2:31])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1C=CC=CC=1>[O:19]([CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][NH:31][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 788644-ChloroquinazolineHCID 235127975-Phenoxypentylamine

Produkt 1

HCID 12928961HCID 12928961, VerbindungAusbeute 19,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To a solution of 1.7 g (0.01 mol) of 4-chloroquinazoline in 50 ml of benzene were added 1.0 g (0.01 mol) of triethylamine and 1.8 g (0.01 mol) of 5-phenoxypentylamine, and the mixture was refluxed for 3 hours. After completion of the reaction, the benzene was evaporated under reduced pressure to leave crystals, which were washed with water, collected by filtration and recrystallized from aqueous ethanol, giving 0.6 g of 4-(5-phenoxypentyl)aminoquinazoline in the form of colorless flakes.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 3 hours
  2. customAfter completion of the reaction
  3. customthe benzene was evaporated under reduced pressure
  4. customto leave crystals, which
  5. washwere washed with water
  6. filtrationcollected by filtration
  7. customrecrystallized from aqueous ethanol

Quellen und Nachweise

ORD-Eintrag
ord-b1a21cd233064625b12b877b47a67c12
Quelldatensatz
uspto-grants-1982_04
Patentnummer
US04323680

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