HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Iodo-6-methylpyridin-3-ol → 4-[(6-Methyl-3-pyridyl)oxy]-6,7-dimethoxyquinoline
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Iodo-6-methylpyridin-3-ol | HCID 89957 | — |
| Edukt | 4-Chloro-6,7-dimethoxyquinoline | HCID 459610 | — |
| Katalysator | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Lösungsmittel | 1,2-Dichlorobenzene | HCID 7239 | — |
| Produkt | 4-[(6-Methyl-3-pyridyl)oxy]-6,7-dimethoxyquinoline | HCID 23156628 | 61,3% |
Reaktionsbedingungen
| Temperatur | 140 °C |
|---|
Reaktionsschritte
4-Chloro-6,7-dimethoxyquinoline (229 mg), 3-hydroxy-2-iodo-6-methylpyridine (486 mg), and 4-dimethylaminopyridine (390 mg) were suspended in o-dichlorobenzene (5 ml), and the suspension was stirred at 140° C. overnight. The reaction solution was cooled to room temperature and was then purified by column chromatography using acetone-chloroform to give the title compound (186 mg, yield 61%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07560558B2 |
| Quelldatensatz | uspto-grants-2009_07 |
| ORD ID | ord-34b0655ea6c04a9ea66bcd791d15dedf |
| Quellennotiz | uspto-grants-2009_07 |