3-Chloro-N,N-dimethyl-1-propanamine → 4-dimethylaminomethyl-8-phenyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one

HRID 2287150

Reaktionsgleichung

Reaktionsgleichung von HRID 2287150
[CH3:1][N:2]([CH2:4]Cl)[CH3:3].CN(C)CCCCl.C([N:21]1[C:26](=[O:27])[C:25]2[CH:28]=[N:29][C:30]3[N:34]([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[N:33]=[CH:32][C:31]=3[C:24]=2[N:23]2[N:41]=[CH:42][N:43]=[C:22]12)(=O)C1C=CC=CC=1>>[CH3:1][N:2]([CH2:4][N:21]1[C:26](=[O:27])[C:25]2[CH:28]=[N:29][C:30]3[N:34]([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[N:33]=[CH:32][C:31]=3[C:24]=2[N:23]2[N:41]=[CH:42][N:43]=[C:22]12)[CH3:3]

Komponenten

4

Edukt 3

HCID 669603-Chloro-N,N-dimethyl-1-propanamineHCID 2630741-Chloro-N,N-dimethylmethanamineHCID 234595924-Benzoyl-8-phenyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one

Produkt 1

HCID 234596234-dimethylaminomethyl-8-phenyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one

Versuchsvorschrift

By substituting dimethylaminomethyl chloride for the 3-(dimethylamino)propyl chloride in the procedure of Example 2 and utilizing 8-phenyl-4H-pyrazolo-[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one product of Example 18 instead of 8-ethyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one, 4-dimethylaminomethyl-8-phenyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H) -one is obtained.

Quellen und Nachweise

ORD-Eintrag
ord-a0a20738db85421f89e75f5bcf7e26a3
Quelldatensatz
uspto-grants-1981_05
Patentnummer
US04269836

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