Ammonium Acetate → 5,6-Dimethyl-2-phenyl-pyridin-3-ol

HRID 228809

Reaktionsgleichung

Reaktionsgleichung von HRID 228809
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=O)[O:5][C:6]=1[CH3:7].C([O-])(=O)C.[NH4+:20]>>[CH3:1][C:2]1[CH:3]=[C:4]([OH:5])[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:20][C:6]=1[CH3:7]

Komponenten

3

Edukt 2

HCID 517165Ammonium AcetateHCID 23078263(4,5-Dimethylfuran-2-yl)-phenyl-methanone

Produkt 1

HCID 230783805,6-Dimethyl-2-phenyl-pyridin-3-olAusbeute 16.079,1 %

Reaktionsbedingungen

Temperatur
250 °C

Versuchsvorschrift

(4,5-Dimethylfuran-2-yl)-phenyl-methanone (1 g) and ammonium acetate (910 mg) were placed in a sealed tube, and the mixture was stirred at 250° C. for 10 hr. The reaction solution was cooled to room temperature, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give 5,6-dimethyl-2-phenyl-pyridin-3-ol (160 g, yield 16%).

Aufarbeitung

  1. temperatureThe reaction solution was cooled to room temperature
  2. customthe solvent was then removed by distillation under the reduced pressure
  3. customthe residue was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-09edd896e4074eec884e88b7cdbc2141
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07560558B2

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