Ammonia → 5,6-Dimethyl-2-(6-methylpyridin-2-yl)pyridin-3-ol

HRID 228819

Reaktionsgleichung

[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=2)=O)[O:5][C:6]=1[CH3:7].[NH3:17]>CO>[CH3:1][C:2]1[CH:3]=[C:4]([OH:5])[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=2)=[N:17][C:6]=1[CH3:7]

Komponenten

Reaktionsbedingungen

Temperatur: 160 °C

Versuchsvorschrift

(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)-methanone (810 mg), methanol (7 ml), and a 28% aqueous ammonia solution (7 ml) were placed in a sealed tube, and the mixture was stirred at 160° C. overnight. The reaction solution was cooled to room temperature, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give 5,6,6′-trimethyl-[2,2′]bipyridin-3-ol (753 mg, yield 93%).

Aufarbeitung

temperatureThe reaction solution was cooled to room temperature
customthe solvent was then removed by distillation under the reduced pressure
customthe residue was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag: ord-a944364cd8f04728b8ddcf3d402af187
Quelldatensatz: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07560558B2

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