Ammonia → 5,6,5'-Trimethyl-[2,2']bipyridin-3-ol

HRID 228823Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 228823
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12](C)[N:11]=2)=O)[O:5][C:6]=1[CH3:7].[NH3:17].[CH3:18]O>>[CH3:1][C:2]1[CH:3]=[C:4]([OH:5])[C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:18])=[CH:12][N:11]=2)=[N:17][C:6]=1[CH3:7]

Komponenten

4

Edukt 3

HCID 222AmmoniaHCID 887MethanolHCID 23078390(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)methanone

Produkt 1

HCID 1363851085,6,5'-Trimethyl-[2,2']bipyridin-3-olAusbeute 68 %

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)-methanone (780 mg), methanol (7 ml), and a 28% aqueous ammonia solution (7 ml) were placed in a sealed tube and were stirred at 160° C. overnight. The reaction solution was cooled to room temperature, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give 5,6,5′-trimethyl-[2,2′]bipyridin-3-ol (529 mg, yield 68%).

Aufarbeitung

  1. temperatureThe reaction solution was cooled to room temperature
  2. customthe solvent was then removed by distillation under the reduced pressure
  3. customthe residue was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-4bfe9740078f4312ab790b03d008545c
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07560558B2

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