Carbonochloridic acid, octyl ester → ethyl 3-[[1-methyl-2-[[N-methyl-4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Carbonochloridic acid, octyl ester	HCID 81956	—
Edukt	1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride	HCID 18412298	—
Produkt	ethyl 3-[[1-methyl-2-[[N-methyl-4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate	HCID 140409596	36%

Reaktionsschritte

Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)-N-methyl-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and n-octyl chloroformate. Yield: 36% of theory, C37H47N7O5 (669.8) ##EQU89##

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06087380
Quelldatensatz	uspto-grants-2000_07
ORD ID	ord-53e206e186d04baa8da8c6c762751ecb
Quellennotiz	uspto-grants-2000_07