Potassium Hydroxide → 6-Amino-1-(4-chloro-benzyl)-1H-pyrimidine-2,4-dione

HRID 2288659Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2288659
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][NH:7][C:8]([NH:10][C:11](=[O:15])[CH2:12][C:13]#[N:14])=[O:9])=[CH:4][CH:3]=1.[OH-].[K+]>CC(O)C>[NH2:14][C:13]1[N:7]([CH2:6][C:5]2[CH:16]=[CH:17][C:2]([Cl:1])=[CH:3][CH:4]=2)[C:8](=[O:9])[NH:10][C:11](=[O:15])[CH:12]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 18432836HCID 18432836, Verbindung

Produkt 1

HCID 15266206-Amino-1-(4-chloro-benzyl)-1H-pyrimidine-2,4-dioneAusbeute 98,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel2×

Versuchsvorschrift

155.6 g of 1-(4-chlorobenzyl)-3-cyanoacetyl-urea in 230 ml of 2-propanol were added to a solution of 14.0 g of KOH in 450 ml of 2-propanol and heated under reflux for 1 hour. After cooling the solid was collected and washed to give the title compound (153.4 g) as a white solid mp 238-41° C.

Aufarbeitung

  1. temperatureheated
  2. temperatureunder reflux for 1 hour
  3. temperatureAfter cooling the solid
  4. customwas collected
  5. washwashed

Quellen und Nachweise

ORD-Eintrag
ord-c44b2503f429465e8f334b29575e659c
Quelldatensatz
uspto-grants-2000_07
Patentnummer
US06090816

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