Trifluoroacetic acid → HCID 178521335, Verbindung

HRID 2289055Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2289055
[N+:1]([C:4]1[CH:45]=[CH:44][C:7]([CH2:8][O:9][C:10]([N:12]=[C:13]([NH:30][C:31]([O:33][CH2:34][C:35]2[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][CH:36]=2)=[O:32])[NH:14][CH2:15][C:16]([NH:18][CH:19]2[CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20]2)=[O:17])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:46][C:47]([F:52])([F:51])[C:48]([OH:50])=[O:49]>ClCCl>[F:46][C:47]([F:52])([F:51])[C:48]([OH:50])=[O:49].[N+:1]([C:4]1[CH:45]=[CH:44][C:7]([CH2:8][O:9][C:10]([N:12]=[C:13]([NH:30][C:31]([O:33][CH2:34][C:35]2[CH:36]=[CH:37][C:38]([N+:41]([O-:43])=[O:42])=[CH:39][CH:40]=2)=[O:32])[NH:14][CH2:15][C:16]([NH:18][CH:19]2[CH2:22][NH:21][CH2:20]2)=[O:17])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 178452375HCID 178452375, Verbindung

Produkt 1

HCID 178521335HCID 178521335, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of the compound (1.92 g), which had been obtained in (1), in anhydrous dichloromethane (10 ml), trifluoroacetic acid (5 ml) was added under ice cooling. The resulting mixture was stirred for one hour, followed by concentration under reduced pressure. The residue was washed with hexane-ether, followed by evaporation of the solvent, whereby 2.78 g of the title target compound were obtained. The product was provided for the subsequent step without purification.

Aufarbeitung

  1. concentrationfollowed by concentration under reduced pressure
  2. washThe residue was washed with hexane-ether
  3. customfollowed by evaporation of the solvent, whereby 2.78 g of the title target compound
  4. customwere obtained
  5. customThe product was provided for the subsequent step without purification

Quellen und Nachweise

ORD-Eintrag
ord-1871abd1f5174d199e0d21ec25e1ecb9
Quelldatensatz
uspto-grants-2000_07
Patentnummer
US06090802

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