4,6-Dichloro-2-ethylpyrimidine → 1-(2-Ethylpyrimidin-4-yl)-4-methyl-piperidine-4-carboxylic acid

HRID 2289550Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2289550
[CH3:1][C:2]1([C:8]([O:10]CC)=[O:9])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH2:13]([C:15]1[N:20]=[C:19](Cl)[CH:18]=[C:17](Cl)[N:16]=1)[CH3:14]>C(O)C.CCN(CC)CC>[CH2:13]([C:15]1[N:20]=[C:19]([N:5]2[CH2:4][CH2:3][C:2]([CH3:1])([C:8]([OH:10])=[O:9])[CH2:7][CH2:6]2)[CH:18]=[CH:17][N:16]=1)[CH3:14]

Komponenten

5

Edukt 2

HCID 5184654,6-Dichloro-2-ethylpyrimidineHCID 19361805Ethyl 4-methylpiperidine-4-carboxylate

Produkt 1

HCID 186980471-(2-Ethylpyrimidin-4-yl)-4-methyl-piperidine-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittel2×HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

1-(2-Ethylpyrimidin-4yl)-4-methyl-piperidine-4-carboxylic acid was prepared on a 3 mmol 4-methyl-4-ethoxycarbonyl-piperidine (as TFA salt) in 7 ml ethanol and 1 ml Et3N treated with a solution of 0.531 g 2-ethyl-4,6-dichloropyrimidine in 4 ml ethanol. After 20 hours at ambient temp. The ethanol was removed and the residue partitioned between water and ethanol, washed with sodium hydrogen carbonate solution and brine. Evaporated to give gum (88.3%).

Aufarbeitung

  1. customThe ethanol was removed
  2. customthe residue partitioned between water and ethanol
  3. washwashed with sodium hydrogen carbonate solution and brine
  4. customEvaporated

Quellen und Nachweise

ORD-Eintrag
ord-612357af215049ceae5b4f7b5693025e
Quelldatensatz
uspto-grants-2000_07
Patentnummer
US06093718

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