2-Chloroaniline → 8-Chloro-2-methylquinoline

HRID 2290605

Reaktionsgleichung

Reaktionsgleichung von HRID 2290605
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[CH:9](=O)/[CH:10]=[CH:11]/[CH3:12]>>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:3]=1[N:4]=[C:11]([CH3:12])[CH:10]=[CH:9]2

Komponenten

3

Edukt 2

HCID 72402-ChloroanilineHCID 447466Crotonaldehyde

Produkt 1

HCID 2211138-Chloro-2-methylquinolineAusbeute 57 %

Versuchsvorschrift

The procedure described in Example 1 was followed, except that 130 g/hour of 2-chloroaniline and 84 g/hour of crotonaldehyde were employed. Distillation from the oil bed under 5 mbar until the bottom temperature reached 250° C., and crystallization of the distillate with xylene, gave 101 g (57% of theory) of 8-chloro-2-methylquinoline of melting point 64° C.

Aufarbeitung

  1. distillationDistillation from the oil bed under 5 mbar until the bottom temperature
  2. customreached 250° C.
  3. customcrystallization of the distillate with xylene

Quellen und Nachweise

ORD-Eintrag
ord-da50df8f3f3f4fb78c0fb85de7b18430
Quelldatensatz
uspto-grants-1986_10
Patentnummer
US04617395

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