Ammonia → HCID 20230261, Verbindung

HRID 2290783Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2290783
Cl[CH2:2][C:3]1[N:7]=[C:6]([CH:8]([CH3:22])[C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[C:11]([F:21])[CH:10]=2)[O:5][N:4]=1.[NH3:23]>>[NH2:23][CH2:2][C:3]1[N:7]=[C:6]([CH:8]([CH3:22])[C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[C:11]([F:21])[CH:10]=2)[O:5][N:4]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 136909413-Chloromethyl-5-(3-fluoro-4-phenyl-alpha-methylbenzyl)-1,2,4-oxadiazole

Produkt 1

HCID 20230261HCID 20230261, Verbindung

Versuchsvorschrift

A mixture of 6.0 g of 3-chloromethyl-5-(3-fluoro-4-phenyl-α-methylbenzyl)-1,2,4-oxadiazole and 50 ml of liquid ammonia was allowed to stand in an autoclave at room temperature overnight. After evaporation of ammonia, the residue was chromatographed over silica gel using chloroform to give 4.05 g of 3-aminomethyl-5-(3-fluoro-4-phenyl-α-methylbenzyl)-1,2,4-oxadiazole as a light brown oil, nD22 1.5878.

Aufarbeitung

  1. customAfter evaporation of ammonia
  2. customthe residue was chromatographed over silica gel

Quellen und Nachweise

ORD-Eintrag
ord-8d6150d967384b67a010ae502266825f
Quelldatensatz
uspto-grants-1986_10
Patentnummer
US04618617

Notizen zur Reaktion

Wird geladen…