1-Bromo-3-chloropropane → 1-(1-Phenylethyl)-4-(3-chloropropyl)piperazine dihydrochloride

HRID 2290869Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2290869
[C:1]1([CH:7]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].Br[CH2:18][CH2:19][CH2:20][Cl:21]>CS(C)=O>[ClH:21].[ClH:21].[C:1]1([CH:7]([N:9]2[CH2:10][CH2:11][N:12]([CH2:18][CH2:19][CH2:20][Cl:21])[CH2:13][CH2:14]2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 80061-Bromo-3-chloropropaneHCID 14797Potassium HydroxideHCID 27371341-(1-Phenylethyl)piperazine

Produkt 1

HCID 201531701-(1-Phenylethyl)-4-(3-chloropropyl)piperazine dihydrochlorideAusbeute 409,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

The procedure described in Example 17(a) was followed, using 16.5 g of 1-(1-phenylethyl)piperazine, 8.0 g of potassium hydroxide, 125 ml of dimethyl sulfoxide and 9.5 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 28.0 g (96% of theory) of 1-(1-phenylethyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

Quellen und Nachweise

ORD-Eintrag
ord-026961c5763949deb439d3b255152346
Quelldatensatz
uspto-grants-1986_10
Patentnummer
US04618677

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