HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Bromo-3-chloropropane → 1-(4-Fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Edukt | Potassium Hydroxide | HCID 14797 | — |
| Edukt | 1-(4-Fluorobenzyl)piperazine | HCID 796563 | — |
| Lösungsmittel | Dimethyl Sulfoxide | HCID 679 | — |
| Produkt | 1-(4-Fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride | HCID 20153168 | 179,2% |
Reaktionsschritte
The procedure described in Example 1(a) was followed, using 32.8 g of 1-(4-fluorobenzyl)piperazine, 30.0 g of potassium hydroxide, 100 ml of dimethyl sulfoxide and 27.0 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 35.2 g (61% of theory) of 1-(4-fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride as a white crystalline solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04618677 |
| Quelldatensatz | uspto-grants-1986_10 |
| ORD ID | ord-7e68371e459f4148b0feaf1d01c2a207 |
| Quellennotiz | uspto-grants-1986_10 |