Ammonia → 4-[2-(2-[2,2,2-Trifluoroethyl]guanidino)pyrid-6-ylthio]butyronitrile

HRID 2291321Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2291321
[F:1][C:2]([F:21])([F:20])[CH2:3][NH:4][C:5](=S)[NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][C:17]#[N:18])[N:8]=1.[NH3:22]>CCO>[F:1][C:2]([F:21])([F:20])[CH2:3][N:4]=[C:5]([NH2:22])[NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][C:17]#[N:18])[N:8]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 537498974-[2-(3-[2,2,2-Trifluoroethyl]thioureido)pyrid-6-ylthio]butyronitrile

Produkt 1

HCID 212797494-[2-(2-[2,2,2-Trifluoroethyl]guanidino)pyrid-6-ylthio]butyronitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 4-[2-(3-[2,2,2-trifluoroethyl]thioureido)pyrid-6-ylthio]butyronitrile (29 g.), yellow mercuric oxide (29 g.) and a saturated solution of ammonia in EtOH (100 ml.) was stirred at room temperature for 24 hours and then filtered. The filtrate was evaporated to dryness and the residue triturated with petroleum ether (b.p. 60°-80°) and collected to give 4-[2-(2-[2,2,2-trifluoroethyl]guanidino)pyrid-6-ylthio]butyronitrile (24 g.), m.p. 89°-91°.

Aufarbeitung

  1. filtrationfiltered
  2. customThe filtrate was evaporated to dryness
  3. customthe residue triturated with petroleum ether (b.p. 60°-80°)
  4. customcollected

Quellen und Nachweise

ORD-Eintrag
ord-d116a4c989cc4fb8b8e39baf6176460c
Quelldatensatz
uspto-grants-1989_01
Patentnummer
US04795755

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