Ammonia → 1-(2-Hydroxyethyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazole

HRID 2291331Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2291331
[OH:1][CH2:2][CH2:3][N:4]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([NH:12][CH2:13][C:14]([F:17])([F:16])[F:15])=S)=[N:5]1.[NH3:18]>CCO>[OH:1][CH2:2][CH2:3][N:4]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([NH2:18])=[N:12][CH2:13][C:14]([F:17])([F:16])[F:15])=[N:5]1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 543739781-(2-Hydroxyethyl)-3-[3-(2,2,2-trifluoroethyl)thioureido]pyrazole

Produkt 1

HCID 212798481-(2-Hydroxyethyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazoleAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 1-(2-hydroxyethyl)-3-[3-(2,2,2-trifluoroethyl)thioureido]pyrazole (20.0 g.) in 5N ammonia in EtOH solution (700 ml.) was added yellow mercuric oxide (64.8 g.) with stirring. Stirring was continued for a period of 2 hours. The mixture was filtered through diatomaceous earth and the solvent then evaporated to dryness in vacuo. The residual oil was triturated with ether to give 1-(2-hydroxyethyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazole (18.5 g.; 99%), m.p. 82°.

Aufarbeitung

  1. stirringStirring
  2. filtrationThe mixture was filtered through diatomaceous earth
  3. customthe solvent then evaporated to dryness in vacuo
  4. customThe residual oil was triturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-3de9a24170f142f390168fe5969e2d72
Quelldatensatz
uspto-grants-1989_01
Patentnummer
US04795755

Notizen zur Reaktion

Wird geladen…