Hydrochloric Acid → N-[4-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride

HRID 2291572Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2291572
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[ClH:21]>>[ClH:21].[CH3:20][S:17]([NH:16][C:13]1[CH:12]=[CH:11][C:10]([N:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)=[CH:15][CH:14]=1)(=[O:18])=[O:19]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 21278916N-[4-(4-Acetylpiperazin-1-yl)phenyl]methanesulfonamide

Produkt 1

HCID 18759927N-[4-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride

Versuchsvorschrift

1-Acetyl-4-(4-methanesulphonamidophenyl)piperazine (9.6 g) and 5N aqueous hydrochloric acid (100 ml) were heated at 100° for 1 hour, the solvent was evaporated, and the residue dried by azeotroping with toluene. The residue was crystallised from ethanol, yield of the title compound 8.26 g, m.p. 230° (dec.).

Aufarbeitung

  1. customthe solvent was evaporated
  2. customthe residue dried
  3. customby azeotroping with toluene
  4. customThe residue was crystallised from ethanol, yield of the title compound 8.26 g, m.p. 230° (dec.)

Quellen und Nachweise

ORD-Eintrag
ord-dc7e346d058b47e6802b42e091e5a229
Quelldatensatz
uspto-grants-1989_01
Patentnummer
US04797401

Notizen zur Reaktion

Wird geladen…