Hydrochloric Acid → 5-(Trifluoromethyl)isoxazol-3-ylamine

HRID 2291709Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2291709
[F:1][C:2]([F:13])([F:12])[C:3]1[O:7][N:6]=[C:5]([NH:8]C(=O)C)[CH:4]=1.Cl>C(O)CO>[F:1][C:2]([F:13])([F:12])[C:3]1[O:7][N:6]=[C:5]([NH2:8])[CH:4]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 212792665-Trifluoromethyl-3-acetylaminoisoxazole

Produkt 1

HCID 156138795-(Trifluoromethyl)isoxazol-3-ylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 174Ethylene GlycolLösungsmittel

Versuchsvorschrift

The reaction was carried out according to the same procedure as described in Example 50 except that 5-trifluoromethyl-3-acetylaminoisoxazole (2.21 g, 11.4 mmole), 36% hydrochloric acid (2.89 g, 28.5 mmole) and ehtylene glycol (11.4 ml) were used. The product was then purified by column chromatography on silica gel and further distilled under reduced pressure to give the title compound. Yield: 1.22 g (70.4%), b.p. 84°-85° C./13.0 mmHg.

Aufarbeitung

  1. customThe product was then purified by column chromatography on silica gel
  2. distillationfurther distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b16fdf4684a24f6ca2d8325886bfd4fa
Quelldatensatz
uspto-grants-1989_01
Patentnummer
US04797492

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