Sodium Bicarbonate → HCID 178468139, Verbindung

HRID 2292131Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2292131
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][CH2:10][O:11][CH2:12][CH3:13])=[CH:4][CH:3]=1.[NH:14]([C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1)[C:15]([NH2:17])=[NH:16].[C:27]([O-:30])([OH:29])=[O:28].[Na+]>N1C=CC=CC=1>[C:27](=[O:28])([OH:30])[OH:29].[NH:14]([C:18]1[CH:26]=[CH:25][C:21]([C:22]([O:1][C:2]2[CH:3]=[CH:4][C:5]([S:8][CH2:9][CH2:10][O:11][CH2:12][CH3:13])=[CH:6][CH:7]=2)=[O:23])=[CH:20][CH:19]=1)[C:15]([NH2:17])=[NH:16]

Komponenten

5

Edukt 3

HCID 516892Sodium BicarbonateHCID 150272734-[(2-Ethoxyethyl)thio]phenolHCID 178512519HCID 178512519, Verbindung

Produkt 1

HCID 178468139HCID 178468139, VerbindungAusbeute 40 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

3.4 g of 2-ethoxyethyl 4-hydroxyphenyl sulfide was dissolved in 50 ml of pyridine. 4-Guanidinobenzoyl chloride was added to the solution under cooling with ice and the mixture was stirred at room temperature for 27 h. A saturated aqueous solution of sodium hydrocarbonate was added thereto under cooling with ice. A precipitate thus formed was recovered by filtration, washed with water and then with acetone, and dried to obtain 2.86 g (yield: 40%) of 4-(2-ethoxyethylthio)phenyl 4-guanidinobenzoate carbonate.

Aufarbeitung

  1. temperatureunder cooling with ice
  2. temperatureunder cooling with ice
  3. customA precipitate thus formed
  4. filtrationwas recovered by filtration
  5. washwashed with water
  6. dry with materialwith acetone, and dried

Quellen und Nachweise

ORD-Eintrag
ord-9368edbbe11b44e594ea7e3808a22c28
Quelldatensatz
uspto-grants-1989_01
Patentnummer
US04801603

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