Sulfuric Acid → 5-Acetamido-2-bromo-4-fluorobenzenesulfonic acid

HRID 2292226

Reaktionsgleichung

Reaktionsgleichung von HRID 2292226
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[C:4]([F:12])[CH:3]=1.[S:13](=O)(=[O:16])([OH:15])[OH:14]>>[C:9]([NH:8][C:5]1[C:4]([F:12])=[CH:3][C:2]([Br:1])=[C:7]([S:13]([OH:16])(=[O:15])=[O:14])[CH:6]=1)(=[O:11])[CH3:10]

Komponenten

3

Edukt 2

HCID 1118Sulfuric Acid2×HCID 67593N-(4-bromo-2-fluorophenyl)acetamide

Produkt 1

HCID 134889635-Acetamido-2-bromo-4-fluorobenzenesulfonic acid

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

N-(4-Bromo-2-fluorophenyl)acetamide (173.2 g) was suspended in conc. sulfuric acid (80 ml), and 60% fuming sulfuric acid (340 ml) was dropwise added thereto at 10° to 20° C., followed by stirring at 20° C. for 2 hours. The reaction mixture was dropwise added to ice water (500 g) at 10° to 20° C., and the precipitated crystals were collected by filtration, washed with cold water (400 ml) and dried under reduced pressure to give 175.8 g of 5-(N-acetylamino)-2-bromo-4-fluorobenzenesulfonic acid. M.P., more than 300° C.

Aufarbeitung

  1. customat 10° to 20° C.
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with cold water (400 ml)
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-736cf34fe595438e9edb816984b3ae21
Quelldatensatz
uspto-grants-1989_01
Patentnummer
US04801408

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